Monday, December 31, 2012

Weston residents co-chair event at Hebrew College

More than 150 members of the Hebrew College community gathered at a special Chanukat Habayit celebration on Dec. 11 to rededicate the campus building in Newton Centre that was almost sold in the wake of mounting institutional debt.

?A great miracle occurred here,? said President Daniel Lehmann, referencing both the Hanukkah miracle of oil and the saving of the Hebrew College building, which the school had put on the market last year.

?Tonight,? he added, ?we not only celebrate our securing this sacred space, we rededicate ourselves to the sacred purpose of Hebrew College to enhance Jewish education and Jewish leadership throughout our community.?

Howard and Elyse Rubin of Weston served as co-chairs of the event.

Source: http://www.wickedlocal.com/weston/news/x1058221307/Weston-residents-co-chair-event-at-Hebrew-College

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Friday, December 28, 2012

A business plan? Start-ups need something else.

A business plan is great once entrepreneurs have tested the market and know what they're going to sell. But for starters, they really need to model their business.

By Dr. Jeffrey R. Cornwall,?Guest blogger / December 27, 2012

In this December file photo, 12-year-old entrepreneur William Zsigo enjoys one of his own chocolate confections as he poses for photos at his home in Haslett, Mich. Before entrepreneurs write up a business plan, they should model their business visually.

Greg DeRuiter/The State Journal/AP/File

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When advising people about what they need to do as they get ready to launch a business, there are two distinct approaches recommended by experts.

Skip to next paragraph Dr. Jeffrey R. Cornwall

Jeff is the Jack C. Massey Chair in Entrepreneurship and Director of the Center for Entrepreneurship at Belmont University in Nashville, Tenn.

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The first, which has been the traditional approach, tells aspiring entrepreneurs that writing a business plan is the first critical step.

In business schools the business plan was the core of our entrepreneurship curriculum for decades. ?Writing a business plan that?s thickness is measured in inches is still a rite of passage in many top entrepreneurship programs.

However, there is a growing chorus of experts questioning why business plans get so much attention.? After all, most entrepreneurs will tell you that once the business gets going it can quickly look fundamentally different than described in their original business plan.

Celebrity Health: 10 Famous Faces Who Fought For Their Health In ...

  • Paula Deen

    The chef notorious for her comfort food shocked fans by <a href="http://www.huffingtonpost.com/2012/01/17/paula-deen-diabetes_n_1210049.html">revealing she has diabetes</a> in January of this year. While the Food Network star had been diagnosed years before, she continued to promote her heavy-on-the-butter recipes until revealing the diagnosis -- <a href="http://www.huffingtonpost.com/2012/02/24/paula-deen-diabetes-reveal_n_1299484.html">at the same time she unveiled a partnership with diabetes drug maker Novo Nordisk</a>. Since then, <a href="http://www.huffingtonpost.com/2012/05/18/paula-deen-diabetes-diet_n_1527794.html">she's lost 30 pounds</a> and has been exercising more and loading up on veggies and salads -- but she hasn't given up the mashed potatoes completely. "I'm a Southern girl, and that's who I am, that's what I know," she told ET.

  • Nick Cannon

    Cannon faced a number of health scares in 2012, including <a href="http://www.huffingtonpost.com/2012/01/04/nick-cannon-mild-kidney-failure_n_1184069.html">kidney problems</a> and <a href="http://www.huffingtonpost.com/2012/02/16/nick-cannon-blood-clots-lungs-pulmonary-embolism-enlarged-ventricle_n_1283151.html">blood clots in his lungs</a>. After stepping down from his radio show to focus on his health, he revealed that he was <a href="http://www.huffingtonpost.com/2012/03/02/nick-cannon-autoimmune-disease-lupus-health_n_1316620.html">diagnosed with the autoimmune disease lupus</a> and a related kidney disorder called <a href="http://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0001512/">lupus nephritis</a>. He has since tuned into what his body needs, and says he feels like he's back on his feet. "<a href="http://www.huffingtonpost.com/2012/10/11/nick-cannon-kidney-disease-awareness_n_1959105.html">I'm healthier now than I was before</a>, so everything is in tip-top shape," he said on a recent HuffPost Live appearance. "I have to get a lot more sleep, I feel like that was maybe one of the stems of what started all of this, cause I never used to sleep. And fatigue would set in."

  • Kate Middleton

    The exciting announcement of a royal baby on the way came with the unfortunate news that <a href="http://www.huffingtonpost.com/2012/12/03/kate-middleton-morning-sickness-hyperemesis-gravidarum_n_2232015.html">The Duchess of Cambridge is suffering from hyperemesis gravidarum</a>, a form of morning sickness characterized by "extreme, persistent nausea and vomiting during pregnancy that may lead to dehydration" and can persist throughout a pregnancy, HuffPost Parents reported. Only about 1 to 2 percent of pregnant women experience such intense symptoms, whereas as many as 80 percent of expectant mothers deal with some type of morning sickness, which typically tapers off after the first trimester.

  • Jack Osbourne

    The former reality TV star and son of Ozzy and Sharon Osbourne realized something was wrong when he <a href="http://www.people.com/people/article/0,,20605555,00.html">started having vision problems</a>. "I couldn't see anything in front of me," he told People magazine. After seeking medical attention, he was <a href="http://www.huffingtonpost.com/2012/06/18/jack-osbourne-multiple-sclerosis-diagnosed-ms_n_1605397.html">diagnosed with the autoimmune disorder multiple sclerosis</a>. While he's resolved to <a href="http://www.huffingtonpost.com/2012/07/09/jack-osbourne-multiple-sclerosis-gma_n_1658662.html">"adapt and overcome,"</a> the new father admits that living with the condition is challenging. "I'm learning that one minute you can be fine, and the next I went blind in my right eye," he said on "The Talk," according to People. <a href="http://www.people.com/people/article/0,,20605803,00.html">"It?s a completely unpredictable disease."</a>

  • Robin Roberts

    The "Good Morning America" co-anchor announced this year that she has a <a href="http://www.huffingtonpost.com/2012/05/18/paula-deen-diabetes-diet_n_1527794.html">rare blood disorder called myelodysplastic syndrome, or MDS</a>, a condition formerly called preleukemia, which causes the bone marrow to produce too few healthy blood cells. In September, she <a href="http://www.huffingtonpost.com/2012/10/04/robin-roberts-bone-marrow-transplant_n_1939635.html">underwent a bone marrow transplant</a> and wrote in a blog post for ABC News that her <a href="http://gma.yahoo.com/blogs/abc-blogs/robin-roberts-journey-thankful-thursday.html">doctors were pleased with the way her body was responding</a>. While she was <a href="http://www.huffingtonpost.com/2012/11/20/robin-roberts-health-update-new-beginning_n_2164938.html">briefly hospitalized in November due to a virus</a>, Roberts has called the transplant a rebirth. <a href="http://www.wwltv.com/wwltv-perfect-match-program/Sally-Ann-Robin-Roberts-interview-180054701.html">"It's a new beginning,"</a> she said in an interview with her sister for New Orleans' WWL-TV. "I look at it as a clean slate and how many people can say at this point in their life that they get a do over? That they get a chance to start again? And that's how I feel, that in many ways I am starting again."

  • Anderson Cooper

    While on assignment in Portugal, the TV personality was <a href="http://www.huffingtonpost.com/2012/12/04/anderson-cooper-blinded-portugal_n_2238027.html">temporarily blinded for 36 hours</a>, after sunlight reflecting off water <a href="http://www.huffingtonpost.com/2012/12/04/eye-sunburn-anderson-cooper-temporary-blindness_n_2239020.html">sunburned his eyeballs</a>. A <a href="http://www.webmd.com/skin-problems-and-treatments/sunburn-and-eye-pain-or-vision-problems">sunburn to the eye</a> can damage the retina or the lens of the eye, causing pain, irritation like something is in the eye and vision loss, according to WebMD. "I wake up in the middle of the night and <a href="http://abcnews.go.com/blogs/health/2012/12/05/anderson-cooper-recovers-from-sunburned-eyeballs/">it feels like my eyes are on fire</a>," he said on his talk show, ABC News reported.

  • Rosie O'Donnell

    On August 20, the comedian wrote on her blog that she <a href="http://rosie.com/my-heart-attack/">had a heart attack the previous week</a>. After helping a heavy woman get out of her car, O'Donnell wrote that she experienced chest pains, nausea and clammy skin, highlighting the <a href="http://www.huffingtonpost.com/2012/02/21/heart-attack-symptoms-women_n_1290952.html">difference in heart attack symptoms for women</a>. She's since started eating more healthy foods, and had <a href="http://www.people.com/people/article/0,,20635664,00.html">lost 12 pounds</a> by October, according to People magazine. "For the first time, it wasn't hard for me," she said about the changes to her diet. "It took a heart attack for me to learn to take care of myself." Earlier in the year, <a href="http://www.huffingtonpost.com/2012/08/27/rosie-odonnell-married-michelle-rounds-_n_1833610.html">O'Donnell's wife Michelle Rounds</a> faced a health scare of her own, when she <a href="http://www.huffingtonpost.com/2012/08/04/michelle-rounds-desmoid-tumors-rosie-odonnell_n_1740270.html">underwent surgery for desmoid tumors</a>, a rare disease characterized by benign tumors that grow quickly in the soft connective tissue of the body.

  • Jesse Jackson Jr.

    The Congressman resigned in November after a medical leave from his position for <a href="http://www.huffingtonpost.com/2012/12/12/jesse-jackson-jr-house-race-wife-sandi-jackson_n_2283810.html">treatment for bipolar disorder</a>. He was <a href="http://www.huffingtonpost.com/2012/08/13/bipolar-ii-disorder-jesse-jackson-jr-mood-disorder_n_1773510.html">diagnosed with bipolar II disorder</a>, which is characterized by less severe periods of mania and longer bouts of depression than bipolar I. He was treated at the Mayo Clinic.

  • Kathy Bates

    The actress revealed to People magazine that she had <a href="http://www.people.com/people/article/0,,20628972,00.html">undergone a double mastectomy after being diagnosed with breast cancer</a>. "After much consideration, I underwent a double mastectomy," she told the magazine. "Luckily, I don't have to undergo radiation or chemo. My doctors have assured me I'm going to be around for a long time." Bates also survived ovarian cancer nine years ago, People reported.

  • Brooke Burke-Charvet

    In November, the "Dancing With The Stars" co-host announced she had been <a href="http://www.huffingtonpost.com/2012/11/08/thyroid-cancer-brooke-burke-charvet_n_2095103.html">diagnosed with thyroid cancer</a>, a less common type of cancer that occurs in the thyroid, a gland near the bottom of the throat involved in hormone functioning. <a href="http://www.huffingtonpost.com/2012/12/13/brooke-burke-charvet-cancer-free-dwts-reveals-cancer-free_n_2293574.html">Seven days after undergoing surgery</a> for the disease, Burke-Charvet <a href="http://www.modernmom.com/blogs/brooke-burke/thyroidectomy-cancer-results-from-the-bu-great-news">wrote on her blog that she's been deemed cancer-free</a>: <blockquote>"I just got the results back from all of my tests and great news -- the thyroid cancer has been removed from my body and all my lymph nodes are clear. So I'm hoping that this is the end of the story. Woohoo!!! And thank GOD!"</blockquote>

  • Source: http://www.huffingtonpost.com/2012/12/26/celebrity-health-crises-2012_n_2303495.html

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    Thursday, December 27, 2012

    Wall St drops for 3rd day, led by retailers

    NEW YORK (Reuters) - U.S. stocks fell for a third straight day on Wednesday, dragged lower by retail stocks after a report showed consumers spent less in the holiday shopping season than last year.

    Many investors said concerns about the "fiscal cliff" kept shoppers away from stores, suggesting markets may struggle to gain any ground until that issue is resolved. The CBOE Volatility Index or VIX, Wall Street's favorite barometer of investor anxiety, rose 4.46 percent, closing above 19 for the first time since November 7.

    A number of 2012's strongest performers advanced, a sign that portfolio managers may be engaging in "window dressing," a practice where market participants buy securities with big gains to improve the appearance of their holdings before presenting the results to clients. Bank of America Corp , which has more than doubled in 2012, added 2.6 percent to $11.54 on Wednesday.

    Holiday-related sales rose 0.7 percent from October 28 through December 24, compared with a 2 percent increase last year, according to data from MasterCard Advisors SpendingPulse. The Morgan Stanley retail index skidded 1.8 percent while the SPDR S&P Retail Trust slipped 1.7 percent.

    "With the 'fiscal cliff' hanging over our heads, it was hard to convince people to shop, and now it's hard to convince investors that there's any reason to buy going into year-end," said Rick Fier, director of trading at Conifer Securities in New York.

    President Barack Obama is due back in Washington early Thursday for a final effort to negotiate a deal with Congress to bridge a series of tax increases and government spending cuts set to begin next week, the so-called "fiscal cliff" many economists worry could push the U.S. economy into recession if it takes effect.

    Coach Inc fell 5.9 percent to $54.13 as the S&P 500's biggest decliner, followed by Amazon.com , down 3.9 percent at $248.63, and Abercrombie & Fitch , off 3.5 percent at $45.44. Ralph Lauren Corp , Limited Brands and Gap Inc also ranked among the S&P 500's biggest decliners.

    The Dow Jones industrial average slipped 24.49 points, or 0.19 percent, to 13,114.59 at the close. The Standard & Poor's 500 Index shed 6.83 points, or 0.48 percent, to 1,419.83. The Nasdaq Composite Index dropped 22.44 points, or 0.74 percent, to 2,990.16.

    J.C. Penney Co was a notable exception to the weakness in retail stocks, surging 4.4 percent to $20.75 as the S&P 500's biggest gainer. It was followed closely by Bank of America and Genworth Financial , which gained 3 percent on the day and 35.5 percent on the year.

    "People want to show they own names like these, making them prime 'window dressing' candidates," said Wayne Kaufman, chief market analyst at John Thomas Financial in New York.

    "Bank of America keeps going up even though it's overbought and you'd expect a pullback at these levels. No one wanted it when it was under $10 a share, but they want it now."

    Volume was light, with only 3.96 billion shares having traded on the New York Stock Exchange, the Nasdaq and the NYSE MKT. Many senior traders were still on vacation during this holiday-shortened week and major European markets were closed for the day.

    The S&P 500 has fallen 1.5 percent over the past three sessions, the worst three-day decline since mid-November. The Dow Jones Transportation Average, viewed as a proxy for business activity, fell 0.6 percent.

    A Republican plan that failed to gain traction last week triggered the S&P 500's recent drop, highlighting the market's sensitivity to headlines centered on the budget talks.

    During the last five trading days of the year and the first two of next year, it's possible for a "Santa rally" to occur. Since 1928, the S&P 500 has averaged a gain of 1.8 percent during that period and risen 79 percent of the time, according to data from PrinceRidge.

    "While it's unlikely there could be a budget deal at any time, no one wants to get in front of that trade," said Conifer's Fier, who helps oversee about $12 billion in assets. "Investors can easily make up for any gains when there's more action in 2013."

    Data showed U.S. single-family home prices rose in October, reinforcing the view that the domestic real estate market is improving, as the S&P/Case-Shiller composite index of 20 metropolitan areas gained 0.7 percent in October on a seasonally adjusted basis.

    Decliners outnumbered advancers on the New York Stock Exchange by a ratio of about 2 to 1, while on the Nasdaq, more than five stocks fell for every three that rose.

    (Editing by Jan Paschal)

    Source: http://news.yahoo.com/wall-st-drops-3rd-day-led-retailers-212805031--finance.html

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    Tuesday, December 25, 2012

    Christmas shopping: A pink kitchen set and the 'buying local' dilemma

    I wasted hours looking for a cheaper version online, when my dad was willing to pay more at the local store. He made me realize that I was all about 'buying local' until I had to shell out more money. I've learned:?I can?t always pay more, but I don?t always have to pay less.

    By Brooke Williams / December 24, 2012

    Junikqul Bracey carries a Disney Ultimate Fairytale Kitchen set toward the checkout at the Target store near Wilmington, N.C. Nov. 22.

    Mike Spencer/Wilmington Star-News/AP

    Enlarge

    My father called me in distress.??I can?t do it, Brookie,? he told me. ?I couldn?t show my face downtown at Haines & Essick if we buy the kitchen online.?

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    He was trying to buy a Christmas present for my three-year-old at a store in Decatur, Ill. where I grew up, but I had found a less expensive toy kitchen online. I shouldn?t have gotten involved, but in my constant pursuit of a better deal, and my inherent cheapness, I didn?t want him to pay too much. Now in addition to squashing his enthusiasm and Christmas spirit, I seemed to be stomping on my father?s moral code.

    Every holiday season, he sends me a check to pick out gifts for my children, except last year. During our Thanksgiving visit to Illinois, Dad got such a kick out of watching his granddaughter pretend to cook he decided she needed her own mini range and refrigerator.

    On his lunch hour from the firm where he has worked since the day he graduated from law school, Dad went to Haines & Essick. The small stationary and gift store has been a Decatur institution since 1902. Today, it is one of the few stores left downtown, which sadly has more parking spaces than places to shop.

    Before we were even back home in Maine, Dad had e-mailed me a picture of a kitchen the store could ship just in time for Christmas. My 70-year-old father had never sent me anything online so his behavior was noteworthy. We do e-mail, but it?s a process that involves his secretary, Ginger, printing out my messages for him to read, and then my Dad dictaphones his response for Ginger to type up and e-mail back to me.

    The kitchen in the picture was fabulous. It had a wooden oven and a microwave, plenty of refrigerator space for fake food and even a drink dispenser ? but the price tag quite literally took my breath away. For a moment, I thought if my father was willing to fork over $300 for a toy maybe I could talk him into remodeling my actual kitchen.

    I spent the morning online pricing other toy kitchens, until I located a pink retro model from the same company for a third of the price.

    My e-mail with the lower-priced model presented my Dad with a quandary: Mrs. Miller in the Haines & Essick?s toy department had spent a lot of time helping him select the kitchen set; it didn?t seem right for him to go buy it cheaper somewhere else.

    By the time he got me on the phone, Dad had been to Haines & Essick four times and was having Ginger hold all his calls while he figured out how to fairly procure his granddaughter?s present. Mrs. Miller could order the pink kitchen I found online, but not at the same price. After discussing numerous scenarios, she conceded that my Dad should take the better deal online. During his third visit, Dad tried to pay Mrs. Miller some arbitrary finder?s fee, handing her a hundred dollar bill that she refused to take.

    In the end, my father bought the pink kitchen from Haines & Essick even though it cost him more.

    I?ve always thrown around the term ?buying local,? and thought I walked the walk: I frequent farm stands and independent bookstores. After college, during my self-righteous phase when I came back home and threw around all the new jargon I learned, I no doubt lectured my father on the importance of ?buying local? and eating ?locally-sourced food? ? things he had done all his life without affixing a fancy term to it.

    My father made me realize that I was all about ?buying local? until I had to shell out more money. Granted I do not have a lot of extra cash, which influences my decisionmaking, but I also waste a lot of time trying to get a perceived deal. I spent four hours looking for a cheaper kitchen, time that I could have been working, and billing, for a grant I was supposed to be writing. It wasn?t even my money. Why was I so determined to get the best deal?

    For my father, whose hero is Abraham Lincoln, buying the cheap kitchen online was a kind of dishonesty.

    Haines & Essick is his store ? the store down the street from his office where people know his name. It?s the store where he has bought Christmas gifts for my brother and me?for 40 years. During my visit home, I was glad to see that it was still there. But I had to admit, if people like me continue to buy everything online or at chain stores, it might not be there in the future. And I know through my work as a grant writer, that it?s the local merchants who sponsor the Little League teams, Meals on Wheels, and other important community programs ? not the big box stores. Local merchants may have to charge more, but they also give back to their communities.

    I realize, I can?t always pay more, but I don?t always have to pay less. I like to think I buy local. My dad actually does.

    Brooke Williams is a freelance writer.

    Source: http://rss.csmonitor.com/~r/feeds/csm/~3/P6azaiFxzjg/Christmas-shopping-A-pink-kitchen-set-and-the-buying-local-dilemma

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    Monday, December 24, 2012

    Life after Sandy: Breezy Point demolitions begin

    David Friedman / NBC News

    The U.S. Army Corps of Engineers oversees the demolition on Saturday of a home in Breezy Point, N.Y. The house floated off its foundation during Superstorm Sandy and came to rest in the middle of Beach 215th Street.

    By Miranda Leitsinger, NBC News

    BREEZY POINT, N.Y. -- The bulldozing of homes ruined by Superstorm Sandy has begun in this seaside enclave, but residents are only beginning to come to terms with the costly and complicated process of rebuilding.

    Neatly dividing what was from what will be, an excavator on Saturday methodically tore down the first badly-damaged Breezy Point home -- a one-story, white home that floated between 150 and 200 feet into the middle of Beach 215th Street during the Oct. 29 storm, apparently stopping only when it slid up against a light pole.

    While the beginning of demolitions is an important milestone on the road to rebuilding, it left resident Tom Ryan, 64, a neighbor of the homeowner, feeling melancholy.

    ?It?s a sad day for Breezy Point, but it?s been a lot of sad days lately for Breezy Point, a lot of sad days,? he said as he walked away from the detritus of the home. ?Sixty-one years (here) all year round, and I?ve never seen anything like this.?

    What Ryan has been seeing is a period of uncertainty in Breezy Point, a private cooperative founded more than a century ago by Irish immigrants. Sandy?s flooding is believed to have triggered a devastating fire that burned down 111 homes in one of the older areas,? known as ?The Wedge.? And the storm surge damaged more than 2,000 other residences, some of which also are not salvageable and are now about to be removed.

    Overall, the storm destroyed 200 buildings and left another 200 unsafe for habitation in the New York City boroughs of Queens, Brooklyn and Staten Island, Department of Buildings spokesman Tony Sclafani said Friday. Many of those structures, which are tagged by ?red cards,? will ultimately be demolished in the coming months, he said.?

    Buildings blocking public rights of the way are the first structures being cleared in New York City, an operation being run by the U.S. Army Corps of Engineers. The removal of these roaming residences will soon be followed by the demolition of the badly damaged structures on private property, a process that the city will oversee.?

    (Coastal communities in New Jersey are going through a similar procedure, though the New Jersey Department of Community Affairs cannot say how many building have been slated for demolition. Gov. Chris Christie has said that more than 22,000 homes were rendered uninhabitable by the storm.)?

    Like other storm victims, residents of Breezy Point focused on salvaging possessions and cleaning up in the first days after Sandy hit. But some soon learned that they might not be able to save their homes, including many bungalows dating back decades when the area was more of a summer getaway known as the ?Irish Riviera.??

    Some hired structural engineers, hoping that their homes could be saved. But in many instances, the answers were not what they had hoped to hear.

    Among those getting the news that their home would have to be torn down were Jerome Hoffman, 62, and his wife, Madeline DiLorenzo-Coscia, 63, who had hoped to put the bungalow back on its foundation but found out that wouldn?t be possible.?

    Miranda Leitsinger / NBC News

    Madeline DiLorenzo-Coscia, 63, and her husband, Jerome Hoffman, 62, look at their 'little frame shack' in Breezy Point on Dec. 8.

    DiLorenzo-Coscia said her family had owned the doomed ?little frame shack,? which was shoved off of its pilings and bombarded with other debris, for more than 50 years.

    ?If you look at it, it?s just a little shack ? but it?s a lifetime full of memories,? she said.? ?It?s like the Wizard of Oz. ? I just wish we could click three times and get back home.??

    Those memories include playing hide and seek under the bungalows as kids, singing tunes like ?Johnny Angel? on the lifeguard stands down on the beach and going on long walks to the point, where she and her friends would read poems they?d written, then tear them up and throw them into the water.?

    ?I guess we thought that we were, you know, we were grownups or something, that we were heroines in our own novels,? she said.?

    The couple would like to rebuild, but they?re struggling with the financial equation. Since it?s a second residence, they?re not eligible for much of the emergency financial aid available to those whose primary residences were damaged by the storm. That means they?d have to refinance their home in Brooklyn to do it and take the same sort of leap of faith that her parents did when they joined the nascent Breezy Point Co-op in 1960 as residents battled to keep their homes after a developer quietly sold the land beneath them.?

    ?They never regretted it. They never looked back and ? I'm sure that, you know, I?ll feel the same because it?s an investment in our children?s future and family being together, family sharing good times,? she said, adding that she wants her 18-month-old grandson, Michael, ?to be able to enjoy this.??

    The co-op board said late last week that the removal of houses deemed unsafe for occupancy or unable to be repaired was expected to begin in the second week of January.?

    The city will oversee destruction of homes on private property, while the Army Corps of Engineers takes down homes that no longer have four walls or are in the right of way, in addition to collecting debris from the city-led demolitions, said Patrick Moes, a spokesman for the corps? New York field recovery office.?

    The process was demonstrated on Saturday, as contractors sprayed the home that floated off its foundation with water in an effort to prevent asbestos particles from going airborne. The debris, which will be tested for asbestos, was then piled into large dumpsters lined with white tarps. Federal environmental and safety officials were onsite, and appliances were separated out so they could be disposed of properly.?

    Workers try to retrieve any mementos that they come across during a demolition, Moes said, and on this day they saved a military-style trunk for the homeowner.? NBC News was unable to contact the homeowner.?

    ?It?s a part of the grieving process,? Moes said of the work. ?Whether it is a pile of debris or a house ? that?s someone?s home.?

    Residents whose homes that stayed put on their property but are beyond saving are racing to complete forms needed for demolition. The co-op board informed them that the city, under the auspices of the Federal Emergency Management Agency, would pay for the demolition of those homes deemed to be a public safety hazard by the buildings department, but only if homeowners complete the paperwork by Dec. 31.?

    As the demolition process beings, residents are eager to begin laying plans for rebuilding. But they must wait for anticipated new building requirements. The co-op said Saturday it is awaiting the release of new FEMA flood zone maps, which will help determine construction criteria.?

    Such concerns are weighing on Pat and Cam Livingstone, whose small oceanfront one-story home will have to be torn down after the floodwaters raced through and thrust a neighbor?s deck against one side of it.?

    John Makely / NBC News

    Pat and Cam Livingstone stand outside their home at 220 Oceanside in Breezy Point, which was floated off of its foundation by Superstorm Sandy.

    Pat Livingstone, 74, said the couple would like to rebuild.?

    ?But you just don't know with the storms that are coming every year, it seems to be,? she said earlier this month, as she and her husband retrieved a few items from the home, including a decades-old top hat and some collector coins. ?We'll have to see, that's where we're at. We have to see. What are they going to let us do? What are the restrictions? Are we going to get insurance???

    Sandy-struck Breezy Point facing 'greatest historical challenge'

    ?They want to go up,? she said, referring to the expectation that authorities will require homes to be elevated several feet. ?Can we walk up? Are there going to be ramps? We're pushing 80 now,? she said with a small chuckle.?

    Cam Livingstone, 76, said the 20 years that the couple lived full time in Breezy Point were some of the best years of their lives.?

    ?We had good times here,? he said, his hand resting on the roof of their badly damaged home. ?We threw some big parties.??

    But now, he said, they wonder if the effort to rebuild would be worth it.

    It ?wouldn't be the money so much,? he said of the possibility of returning, but ?do we want to take another chance at this stage of our life??

    Down the promenade from the Livingstones, Bob Hauck, a 58-year-old plumber, has decided it is a risk worth taking.

    The storm scooped his oceanfront single-story home off its foundation and plopped it down 100 feet straight back, in a sandy area. He joked that the address of his home should now be 210 Sand Lane instead of 210 Oceanside.

    John Makely / NBC News

    Bob Hauck looks over what is left of his home at 210 Oceanside in the Breezy Point neighborhood of Queens, NY.

    ?It?s just mind boggling,? he said of the house he owned for 25 years. ?I?m just trying to picture how it lifted and got pushed back and actually came down, you know, pretty intact.?

    Gone are the picture window with a double sash that once offered a full panorama of the Atlantic Ocean, as well as the big front deck where Hauck would smoke a cigar and visitors would drop by to say hello. Water warped the floor, in places shoving it up two feet, and pushed in the kitchen wall.?

    ?Melancholy's an understatement. It?s suppressed grief, it?s suppressed grief,? he said of the state of his home. ?There are no options, you know, in regard to this home. ? the cards are dealt, and we have to play our hand.?

    Hauck, a father of four adult children who started coming to this shoreline community with his parents decades ago, said he has ?Breezy sands in my shoes.? It will take all of his financial resources to come back, he said, but he will do it.?

    ?The beach was our home, and it was a special home because it was a home of a bygone era,? he said, calling it ?a piece of heaven on Earth.??

    Hauck said he has been motivated by his neighbors, who have been quick to pick up the pieces of their shattered lives, with some even moving back in though water only just became available in one section of the community on Saturday.

    He?s ready to do the same.

    ?It?s like a dream I know I am not going to wake up from. ? It wasn?t the long term plan, but we?ve got to take what we?re given,? he said, adding that he told his family, ?We had a great run and we?ll have another great one.?

    Madeline DiLorenzo-Coscia's "little frame shack" is just one of the homes that will be demolished in Breezy Point. (John Makely / NBC News)

    More content from NBCNews.com:

    Follow US news from NBCNews.com on Twitter and Facebook

    ?

    Source: http://usnews.nbcnews.com/_news/2012/12/24/16111442-superstorm-sandy-residents-consider-future-as-demolitions-begin-in-breezy-point?lite

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    "What are some cool things I can do with an unused 16GB Nook tablet?"

    Sorry, Readability was unable to parse this page for content.

    Source: http://feeds.gawker.com/~r/lifehacker/full/~3/8FWg6TNJhtw/what-are-some-cool-things-i-can-do-with-an-unused-16gb-nook-tablet

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    Sunday, December 23, 2012

    Two toddlers die in Chicago apartment fire

    By Michelle Relerford and Alexandra Clark, NBC Chicago

    Two toddlers who died in a fire early Saturday morning were left alone with two other young boys when the blaze broke out inside their Chicago apartment on the city's southside, police said.

    Family and friends gathered Saturday evening for a vigil to honor 2-year-old Jariah and 3-year-old Jarvis. The boys were alone with a 7-year-old and a 4-year-old when the fire ignited.

    Neighbor Tiffany Williams recounted what the boys who escaped told her: "They said they heard the baby crying, beating on the door but they couldn't go back to get her cause they were choking on the smoke."

    Read more at NBC Chicago

    Authorities believe a hot plate used for heat sparked the flames, but the cause remains under investigation. When the fire started, a relative helped the two older boys to safety, but Jariah and Jarvis stayed trapped inside the apartment.


    A resident who called 911 just before 3:30 a.m. told authorities that young children were trapped inside the burning home in the 6400 block of South Paulina Street in the West Englewood area, Fire Media Affairs Director Larry Langford said. When firefighters arrived, the fire had blown out a window, with the open air feeding the flames.

    ?Everybody concentrated and made a frantic search to find them,? Langford said.

    But ?extensive? fire made it difficult for firefighters to reach the rear bedroom where the fire started, and where the children were located.

    Witnesses said the children's mother was frantic.

    "She was going crazy, no one could control her," Williams said.

    Firefighters used a saw to cut the bars off a basement window in an attempt to reach the children, but they were unable to rescue the toddlers in time. They later found the children's bodies in the three-bedroom apartment on the first floor of the two-story gray stone building.

    Fire investigators continue to sort out what caused the fire. They are also talking with the mother, who police said left the four children home alone.

    "They said their mother was getting dressed told them to go in their room and go to sleep," said Williams. "They said they were left there alone and they'd been there by themselves for a long time."

    The two surviving children were taken into the custody of Illinois Department of Children and Family Services.

    Crews have not found any working smoke detectors in the home, Langford said. The Chicago Fire Department canvassed the neighborhood on Saturday, starting at 10 a.m., to pass out smoke alarms and share fire safety information.

    ?

    Source: http://usnews.nbcnews.com/_news/2012/12/22/16095857-two-toddlers-die-in-chicago-apartment-fire-no-adults-were-home?lite

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    Friday, December 21, 2012

    meiraonline: 10 reasons for starting a profitable home business online.


    It's possible to start a home business online with very little

    outlay and you can easily earn from $100 to thousands per day.

    Keywords:

    internet, online income, money, business,web, internet

    Article Body:

    It's possible to start a home business online with very little

    outlay and you can easily earn from $100 to thousands per day.

    1. You want to escape the rat race. You'd rather spend the 2 hours

    you waste every day with your family, or on a hobby. Running your

    own business online you can stop the commute, and you can feel good

    because you are helping to cut pollution too.

    2 You can work part time building your new home business online until

    you see it taking off. You aren't giving up your bill paying regular

    job to jump in without any income.

    3 It's possible to start a home business online with very little

    outlay. Webhosting is cheaper than a bricks and mortar shopfront.

    You already have the pc to access the net, it can start working

    for it's keep.

    4 You can choose your own hours. If you have an appointment to keep

    in the morning, start your online work in the afternoon. No one can

    tell you "you can't have that week off in August, Bill got in first"

    5 If you work harder you can benefit directly, you put more hours in

    and your online business makes more profit, your wages go up. Your

    salary isn't fixed by someone elses view of what you're worth.

    6 A lot of online business tasks can be automated, using readily

    available tools. Emails can be automatically sent by

    autoresponders, even regularly asked questions can be sorted and

    answered by software.

    7 A website works 24 hours a day without complaining. Even if you're

    on holiday your online business website can be working online for

    you bringing in money.

    8 Your online business can be as far reaching as you want, it can

    offer something for your local community. It can equally sell to

    people around the world, without penalty. It doesn't cost any extra

    to send an email to Australia, or for your website to be used to

    make a purchase by someone in Europe.

    9 Starting a home business online means you have a continuously

    growing market as more and more people come online everyday.

    10 It's dress down day everyday. You can work in your pyjamas if you

    want, nobody's going to stop you in your own home. No more suits and

    ties unless you want to wear them, but that's your choice.

    Source: http://meiraonline.blogspot.com/2012/12/10-reasons-for-starting-profitable-home.html

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    Wednesday, December 19, 2012

    SnapKeys SI launches for Android in private beta

    SnapKeys SI has launched for Android as of today. SnapKeys SI, for those unfamiliar is a keyboard replacement. More specifically, a keyboard replacement that is said to be social, simple, fast and intelligent. And as you will likely see in the image and video included in this post ? SnapKeys SI is a keyboard replacement with a rather unique look.

    what-is

    Touching on that look, the folks at SnapKeys note that because the keyboard has only four keys and a few letters it becomes a simple and intuitive way to enter text. For right now we are going to have to take their word. As of right now, the SnapKeys SI app has launched and is available only as a private beta.

    The keyboard shows four vowels; A, O, I and E along with eight other letters that you use most often. You will begin your typing by hitting one of the boxes that contains the letter you need. And if for some reason you need a letter that is not shown, you tap in the middle, between the boxes. The space bar is on the right-hand side and the back space key is over on the left side.

    Of course, as one would assume given the limited keys displayed, SnapKeys SI will predict your words as you type. Word suggestions appear on the right-hand side with the word you are typing appearing in blue. Special characters can be accessed by pressing and holding the space or back space keys. And similar to other predictive solutions, SnapKeys SI will learn your typing style over time.

    With that, those looking to give SnapKeys SI a look will need to head on over to the SnapKeys website, click the blue Download Beta button and fill out the short form. From that point, it looks like you will be added to the beta list

    Source: http://androidcommunity.com/snapkeys-si-launches-for-android-in-private-beta-20121218/

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    Tuesday, December 18, 2012

    10 Most overpaid coaches in CBB - IlliniHQ Forums

    Jump to content

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    #1 User is offline ? PBLIllini?

    • Group: Members
    • Joined: 30-August 08

    Posted Yesterday, 02:23 PM

    http://www.lostlette...paid-coaches/#4

    The biggest elephant in the room during Weber?s tenure at Illinois is that he rode the coattails of Illini predecessor Bill Self and his stud recruits (namely Dee Brown and Deron Williams) to his most successful years.

    That theory gained momentum in the seasons after Williams and Brown left as Weber failed to find success with his own recruits. Considering the school?s natural (one would think) in to the bevy of great players in Chicago, it was rather inexcusable on Weber?s part. Thus Weber was fired last season after a woeful 17-15 year.

    Yet somehow Kansas State is confident that Weber can lure recruits to the Little Apple. Confident enough that they?re already paying Weber more than they paid former coach Frank Martin ($1.3MM), even though Martin is widely considered a better coach and recruiter.

    0


    #2 User is offline ? Tempo34?

    • Group: Members
    • Joined: 01-August 08

    Posted Yesterday, 02:27 PM

    Anyone with Weber on the payroll is getting ripped off.

    0


    #3 User is offline ? brs7?

    • Group: Members
    • Joined: 01-March 10

    Posted Yesterday, 02:49 PM

    An interesting question is how many of these coaches will stay one step ahead of the sheriff and at least make a lateral move (perhaps even to one of these jobs - LOL.)

    Of these, i would say Travis Ford may be a man whose best years are still ahead of him.

    0


    #4 User is offline ? CUtoCU?

    • Group: Members
    • Joined: 21-February 12

    Posted Yesterday, 03:31 PM

    It is interesting that the list includes Sendek. Many a Weber loyalist used Sendek as a cautionary tale, since they argued that NC State ran him out of town and proceeded to get worse under Lowe.

    Newsflash Weberites, both Sendek and Weber still suck! And both schools were right in pushing them out; only difference is Sendek pulled a Tubby and left before he got axed.

    0



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    Source: http://forums.illinihq.com/topic/25761-10-most-overpaid-coaches-in-cbb/

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    Scientists discover evidence of giant panda's population history and local adaptation

    Dec. 16, 2012 ? A research team, led by Institute of Zoology of Chinese Academy of Sciences and BGI, has successfully reconstructed a continuous population history of the giant panda from its origin to the present. The findings suggested whereas global changes in climate were the primary drivers in panda population fluctuation for millions of years, human activities were likely to underlie recent population divergence and serious decline. This work reveals a good example for assessing and establishing the best conservation method for other endangered species.

    The latest study was published online in Nature Genetics.

    The giant panda is the rarest member of the bear family. Looked upon as the ambassador for all endangered species, it is a well-recognized symbol of international wildlife conservation. The giant panda is currently threatened by continued habitat loss, human persecution, among others. Its dietary specialization, habitat isolation, and reproductive constraints have led to a perception that this is a species at an "evolutionary dead end," destined for deterministic extinction in the modern world.

    In this study, researchers carried out whole genome resequencing of 34 wild giant pandas and found the current six geographic populations of giant panda could be divided into three genetic populations, including Qinling (QIN), Minshan (MIN) and Qionglai-Daxiangling-Xiaoxiangling-Liangshan (QXL). Through reconstructing giant panda's population history, they found several important evolutionary events such as two population expansions, two bottlenecks and two population divergences.

    The giant panda has a very special bamboo diet, while its ancestor was omnivorous or carnivores. As early as about 3 Myr ago, they probably had already completed their dietary swift and pygmy panda emerged with bamboo as its primary diet. The warm and wet weather at that time provided ideal conditions for the spread of bamboo forests that further led to the first population expansion of giant panda. However, about 0.7 Myr ago, the panda population began to decline due to the two largest Pleistocene glaciations happened in China, and its first population bottleneck occurred at about 0.3 Myr ago. During that period, pygmy panda was gradually replaced by another subspecies -- baconi panda that has larger body size.

    After the retreat of the Penultimate Glaciations, giant panda's second population expansion happened and it reached its population peak between 30~50 thousand years (kyr) ago. The warm weather in the Greatest Lake Period (30~40 kyr ago) and alpine conifer forest may play an important role in the flourishing of the panda population. However, during the period of last glacial maximum (LGM), the climate was cold, dry, and inhospitable with frequent storms and a dust-laden atmosphere. Under such harsh environment, extensive panda habitats were loss and its second population bottleneck occurred.

    The more recent panda population history showed that the panda population separated into Qinling (QIN) and non-QIN populations at about 0.3Myr ago, and then the non-QIN cluster diverged into two populations, the Minshan (MIN) and Qionglai-Daxiangling-Xiaoxiangling-Liangshan (QXL) at about 2.8 KYA ago. Subsequently, the three populations were different in the ways of fluctuation. For example, there was a drastic decline in the QIN, a slight increase in the MIN and a more remarkable growth in the QXL populations.

    Researchers identified the signals of panda's local adaptation. They found the largest group of selected genes in these populations was related to sensory system. However, the two genes, Tas2r49 and Tas2r3, were associated with bitter taste and were under directional selection between the QIN and non-QIN populations, showing no signal of directional selection between MIN and QXL populations.

    As a form of olfactory communication, odor perception is crucial for reproduction and survival of giant pandas in the dense forest. Researchers found the MIN and QXL populations had fewer directionally selected genes than QIN and non-QIN, suggesting less variation happens in the selection processes between MIN and QXL. They also found the evidence that population fluctuations were driven by global climate shifts, but recent human activities have likely caused population divergence and the serious recent decline.

    Shancen Zhao, Project Manager from BGI, said, "We have identified three genetic populations of giant panda for the current six geographic populations lived in western of China. The varied local adaptations found in our study provide invaluable resource for researchers to better select effective conservation methods to rescue the giant panda even other endangered species. The translocation of wild-caught individuals or releasing the captive-bred ones may be a feasible approach. "

    Share this story on Facebook, Twitter, and Google:

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    Story Source:

    The above story is reprinted from materials provided by BGI Shenzhen.

    Note: Materials may be edited for content and length. For further information, please contact the source cited above.


    Journal Reference:

    1. Shancen Zhao, Pingping Zheng, Shanshan Dong, Xiangjiang Zhan, Qi Wu, Xiaosen Guo, Yibo Hu, Weiming He, Shanning Zhang, Wei Fan, Lifeng Zhu, Dong Li, Xuemei Zhang, Quan Chen, Hemin Zhang, Zhihe Zhang, Xuelin Jin, Jinguo Zhang, Huanming Yang, Jian Wang, Jun Wang & Fuwen Wei. Whole-genome sequencing of giant pandas provides insights into demographic history and local adaptation. Nature Genetics, 2012; DOI: 10.1038/ng.2494

    Note: If no author is given, the source is cited instead.

    Disclaimer: Views expressed in this article do not necessarily reflect those of ScienceDaily or its staff.

    Source: http://feeds.sciencedaily.com/~r/sciencedaily/~3/21Wy8KjtKXU/121216132511.htm

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    Monday, December 17, 2012

    Apple sold over two million iPhone 5s in China in first weekend

    Even though there were no insanely long lines to rave about this time, Apple's now showing some big numbers merely three days after its iPhone 5 launch in China. According to the short press release fresh out of the oven, Cupertino's Chinese division has so far managed to sell over two million iPhone 5s through various channels (notably with online reservation for Apple's in-store purchases, as already implemented in Hong Kong), thus "setting a new record with the best first weekend sales ever in China," said CEO Tim Cook. To put that into context, the iPhone 5's original opening weekend sales topped five million in nine countries, which is again solid proof that "China is a very important market" for Apple. Or maybe the Mayan calendar really made an impression among Chinese consumers.

    Continue reading Apple sold over two million iPhone 5s in China in first weekend

    Filed under: , ,

    Comments

    Source: http://www.engadget.com/2012/12/16/apple-iphone-5-china-opening-weekend/

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    Sunday, December 16, 2012

    Board challenged after death - Stuff

    The family of a Picton woman who died during surgery say they have lost faith in the Nelson Marlborough District Health Board and never want the surgeon to operate again.

    Rachel Riddell, 31, died of significant blood loss in January 2011 after having her gall bladder removed by Michael Parry at Wairau Hospital in Blenheim.

    The Zimbabwean-born surgeon, who is linked to another death and two other botched operations, has not operated on patients since May.

    Riddell's older sister, Lynn Weir, said her family were still waiting to find out what went wrong in the operating theatre.

    Riddell, who was raised as a Jehovah's Witness, had signed a directive against blood transfusions.

    She thought she was going in for laparoscopic, or keyhole, surgery, but medical notes show Parry converted to open surgery halfway through the operation.

    Riddell was dropped at the hospital about 7.30am by her mother, who had planned to return to sit with her until she was discharged later that day.

    "I think it was around 2.30pm that they rung and said, ?Look your daughter's in trouble, she's in major trouble, she's dying basically'," Weir said.

    Riddell was taken back into theatre about 3pm, but died that evening.

    "It's been very traumatic for my parents, you know, not being able to lay it to rest because they still don't know what happened.

    "For me I want it over and done with, and I want to know what went wrong.

    "But I also want to ensure that our DHB is employing people with good health records."

    Weir said she did not have faith in the district health board, which employed Parry in April 2010.

    "They've spent so long coming out to the public going . . . ?We have confidence in this surgeon'. Well, how do you have confidence in this surgeon and let him continue?"

    Parry was stood down on full pay after the death of Jim Nicholls, 80, who suffered massive blood loss during an operation on May 24.

    At the same time, Southern Cross suspended his contract as an affiliated provider, and he stopped operating at Churchill Trust Private Hospital in Blenheim.

    A coroner's inquiry into the two deaths was put on hold when police launched their own investigation into one of the deaths, to determine whether there was any "liability or culpability".

    Police are refusing to confirm which death - Nicholls' or Riddell's - is being investigated.

    As well as the police inquiry, the Medical Council is investigating other complaints against Parry that were referred to it by the health and disability commissioner.

    Two women complained after they suffered serious complications during Parry operations. Both went in to have their gall bladders removed and had to be sent to Christchurch Hospital for follow-up care.

    "Me talking and getting this case out in the open, she would support me 100 per cent," Weir said.

    The family laid a complaint with the health and disability commissioner in May last year.

    Nelson Marlborough chief medical officer Heather McPherson maintained the quality of service at Wairau Hospital was of a "good standard" and patient safety was of the highest priority.

    WAIRAU HOSPITAL CASES

    December 2010: Picton mother Angie Webber, 26, went in to have her gall bladder removed by Parry. Her bile duct was damaged and she was sent to Christchurch Hospital, where a specialist performed open surgery to repair the damage. January 2011: Rachel Riddell, 31, of Picton, died from massive blood loss following surgery to have her gall bladder removed. February 2011: A 36-year-old Upper Hutt woman suffered complications during surgery to remove her gall bladder. She, too, needed further treatment in Christchurch. May 2012: Jim Nicholls, 81, died after blood loss during surgery to remove a hernia and gall bladder.

    - ? Fairfax NZ News

    Source: http://www.stuff.co.nz/the-press/news/8083465/Board-challenged-after-death

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    Saturday, December 15, 2012

    Charlotte Home Sales Rebounding | Charlotte Communities| Real ...

    Charlotte Home sales surged 35% higher in November, thats in units sold, compared with November 2011, continuing the year long trend of advancing sales and increasing prices. ?Home Prices continue their gradual increases.

    Why? Is the economic rebound so strong? Or is there another Reason? Take a look at this telling chart below, or what $1100 per month will buy in a house today, at 3.25% interest rates.

    My first home, in the early 1980?s cost me about $1100/month, and it cost $85,000. ?So first home buyers you are in luck. Just don?t overbuy.

    Yesterday, Chairman of the Federal Reserve Ben Bernanke announced interest rates would stay close to zero until we get below 6.5% unemployment. 2012 is going to be a good year around the country.

    Buyers need to continue to buy smart! ?Buy what you need for the next 5 years, and resist the urge to overbuy.

    Buyers Markets Becoming Sellers Markets In Charlotte

    Good news for home Sellers in Charlotte! Across the area, home inventories are down, new home inventory is low, and many of Charlotte?s favorite zip codes have fewer than 6 months of inventory, some only ?3-5 months! Many of these same zip codes had 11 and 12 months of inventory a year ago.

    In real estate , we condsider 3 months or less an Extreme Sellers Market, and 3-6 months of inventory, an average Sellers Market. See whats going on in your south Charlotte zipcode, and price range at our November Real Estate Market Report

    This continues the trend seen all summer of gradually rising prices and very sturdy increases in unit sales since April. ?Before getting too excited know that there are still hurdles on the high end, and further into the suburbs, but never the less 2013 will show an improvement over 2012. ?tm

    Related Posts

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    Source: http://charlottecommunitiesonline.com/2012/12/13/charlotte-home-sales-rebounding/

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    Thursday, December 13, 2012

    Senate Dems offer Sandy disaster aid package

    (AP) ? Senate Democrats have quickly cobbled together a $60.4 billion disaster aid package for New York, New Jersey and other states hit by Superstorm Sandy in late October.

    Working from the emergency spending request President Barack Obama made five days ago, the Senate Appropriations Committee on Wednesday released draft of the legislation.

    While the bill calls for $60.4 billion, the Congressional Budget Office estimates that only about $9 billion would be spent over the next nine months. An additional $12 billion would be spent the following year.

    The bill is laden with big infrastructure projects that often require years to complete.

    Associated Press

    Source: http://hosted2.ap.org/APDEFAULT/89ae8247abe8493fae24405546e9a1aa/Article_2012-12-12-Superstorm%20Aid/id-ed87f7864a614704911b1716f54267e0

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    Wednesday, December 12, 2012

    Does the brain become unglued in autism?

    Dec. 11, 2012 ? A new study published in Biological Psychiatry suggests that autism is associated with reductions in the level of cellular adhesion molecules in the blood, where they play a role in immune function.

    Cell adhesion molecules are the glue that binds cells together in the body. Deficits in adhesion molecules would be expected to compromise processes at the interfaces between cells, influencing tissue integrity and cell-to-cell signaling. In the brain, deficits in adhesion molecules could compromise brain development and communication between nerve cells.

    Over the years, deficits in neural cell adhesion molecules have been implicated in schizophrenia and other psychiatric disorders. One adhesion molecule, neurexin, is strongly implicated in the heritable risk for autism.

    Cell adhesion molecules also play a crucial role in regulating immune cell access to the central nervous system. Prior research provided evidence of immune system dysfunction in individuals diagnosed with autism spectrum disorder (ASD). This led scientists from the University of California, Davis to examine whether adhesion molecules are altered in children with ASD.

    To conduct the study, they recruited 2-4 year old children, 49 of whom were diagnosed with an ASD and 31 of whom were typically developing. They measured blood plasma levels of multiple molecules, conducted behavioral assessments, and measured head circumference in all participants.

    "For the first time, we show that levels of soluble sPECAM-1 and sP-selectin, two molecules that mediate leukocyte migration, are significantly decreased in young children with ASD compared with typically developing controls of the same age," explained the authors. "This finding is consistent with previous reports of decreased levels of both sPECAM-1 and sP-selectin in adults with high-functioning autism."

    They also found that repetitive behavior scores and sPECAM-1 levels were associated in children with ASD. Repetitive, stereotyped behaviors are a typical feature of ASD and these data suggest a potential relationship between molecule levels and the severity of repetitive behaviors.

    Finally, they also discovered that head circumference was associated with increased sPECAM-1 levels in the typically developing children, but not in the children with ASD. This indicates that perhaps sPECAM-1 plays a role in normal brain growth, as larger head circumference is a known feature of individuals with autism.

    "The report of reductions in adhesion molecules in blood in autism is interesting in light of recent genetic findings. However, the importance of these measurements remains somewhat uncertain," commented Dr. John Krystal, Editor of Biological Psychiatry. "Our field continues to look for blood tests that might inform the diagnostic and treatment process."

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    Story Source:

    The above story is reprinted from materials provided by Elsevier, via AlphaGalileo.

    Note: Materials may be edited for content and length. For further information, please contact the source cited above.


    Journal Reference:

    1. Charity E. Onore, Christine Wu Nordahl, Gregory S. Young, Judy A. Van de Water, Sally J. Rogers, Paul Ashwood. Levels of Soluble Platelet Endothelial Cell Adhesion Molecule-1 and P-Selectin Are Decreased in Children with Autism Spectrum Disorder. Biological Psychiatry, 2012; 72 (12): 1020 DOI: 10.1016/j.biopsych.2012.05.004

    Note: If no author is given, the source is cited instead.

    Disclaimer: This article is not intended to provide medical advice, diagnosis or treatment. Views expressed here do not necessarily reflect those of ScienceDaily or its staff.

    Source: http://feeds.sciencedaily.com/~r/sciencedaily/mind_brain/child_development/~3/QX4iRvAuiLc/121211083037.htm

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