Wear Your Vegetables: Could Broccoli Hold the Key to Skin Cancer Prevention?

With skin cancer emerging as one of the world's most prevalent forms of cancer, researchers are using every tool at their disposal to fight this disease. The tool of choice for Sally Dickinson? Broccoli.

A diet heavy in cruciferous vegetables, such as broccoli sprouts, has shown potential risk-reduction properties for colorectal, prostate and various other forms of cancer. Dickinson's research currently focuses on how sulforaphane ? a naturally occurring compound in broccoli with established chemopreventive properties ? could possibly be used to help patients reduce their risk for skin cancer.

What sets Dickinson's research apart? Instead of eating broccoli to unlock the risk-reduction nutrients, she's asking patients to apply small doses of sulforaphane to their skin. Think of it as a broccoli-based sunscreen additive.

"Even though there is heightened awareness about the need for limited sun exposure and use of sunscreens, we're still seeing far too many cases of skin cancer each year," Dickinson said. "We're searching for better methods to prevent skin cancer in formats that are affordable and manageable for public use. Sulforaphane may be an excellent candidate for use in the prevention of skin cancer caused by exposure to ultraviolet rays."

Dickinson, a research assistant professor in the pharmacology department at the University of Arizona and a UA Cancer Center member, began investigating broccoli's chemopreventive properties when she began her postdoctoral studies in 2005 in the laboratory of Tim Bowden, one of the UACC's most influential research scientists. Prior to joining Dr. Bowden's laboratory, Dickinson earned her doctorate through the Genetics Graduate Interdisciplinary Program at the UA, studying oxidative stress and heart disease.

Under Bowden's guidance, Dickinson pursued her postdoctoral training and built up an impressive list of credentials in her own right. As Dr. Bowden transitions into retirement, Dickinson will take over the majority of his lab's ongoing projects, including this in-depth look into sulforaphane.

"I learned so much from working with Dr. Bowden," Dickinson said. "He is a hypothesis-driven, old-school scientist who quietly extracts the best out of everyone around him. I'm truly honored that he's handing his lab's reins over to me."

So how would topical broccoli-based ointments differ from the products currently available in stores? Dickinson's research shows that sulforaphane is a highly adaptable, highly effective agent when it comes to inhibiting cancer-causing pathways (such as the AP-1 protein), while activating chemoprotective genes (such as the Nrf2 gene).

Her pilot study in collaboration with Johns Hopkins University will test a topical broccoli sprout solution on the skin a group of patients to see if the compound is effective in the context of solar simulated light. Previous studies have shown that the extract is quite safe for both topical and oral administration.

If the research proves to be successful, Dickinson believes this could lead to even more applications for sulforaphane.

"Sulforaphane is the kind of compound that has so many incredible theoretical applications if the dosage is measured properly," Dr. Dickinson said. "We already know that it is very effective in blocking sunburns, and we have seen cases where it can induce protective enzymes in the skin."

Someday, patients with compromised immune systems may be able to apply sulforaphane to their skin in order to reduce their risk of skin cancer. Sulforaphane is one of the many natural products and pharmaceutical agents being explored for use in topical prevention of UV-induced skin cancers through the Chemoprevention of Skin Cancer Program Project Grant, headed by Bowden and UACC's Dr. David Alberts.

Dickinson's research could potentially lead to a day when parents are instructing their children to not only eat their vegetables, but to wear them, as well.

Source: http://uanews.org/story/wear-your-vegetables-could-broccoli-hold-the-key-to-skin-cancer-prevention

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Powerball jackpot at $400M after no weekend winner

FILE- In this Nov. 28, 2012, file photo, Powerball numbers are chosen in the $579.9-million game drawing at the Florida Lottery in Tallahassee, Fla. No one hit the Powerball jackpot on Saturday, Aug. 3, 2013, so the $400-million prize will roll over for the next drawing on Wednesday. (AP Photo/Phil Sears, File)

FILE- In this Nov. 28, 2012, file photo, Powerball numbers are chosen in the $579.9-million game drawing at the Florida Lottery in Tallahassee, Fla. No one hit the Powerball jackpot on Saturday, Aug. 3, 2013, so the $400-million prize will roll over for the next drawing on Wednesday. (AP Photo/Phil Sears, File)

DES MOINES, Iowa (AP) ? No one hit the Powerball jackpot this weekend, so the money will roll over and create a roughly $400 million prize for Wednesday's drawing.

The midweek jackpot remains below the record $590.5 million jackpot won in May by an 84-year-old Florida woman. But as it stands, it would be the third-largest Powerball jackpot ever and the fourth-largest lottery prize on record.

Saturday's winning numbers were 21, 24, 36, 42 and 45; the Powerball was 15.

The changes Powerball organizers made to the game last year are coming to roost in the billowing jackpots, with Wednesday's pushing into record territory less than three months after Gloria C. Mackenzie of Zephyrhills, Fla., claimed the biggest Powerball prize ever.

Powerball tickets doubled in price to $2 in January 2012 as part of a plan to help jackpots grow bigger, faster. And when the jackpots reach astronomical levels, ticket sales take off, with jackpots following close behind.

If Wednesday's jackpot doesn't top $400 million, a single winner choosing the cash option would collect $230.3 million before taxes.

No matter how many people play the game, the odds of matching all six numbers remains 1 in 175.2 million.

Half of the $2 cost of a Powerball ticket goes toward the prizes, the rest to the state lottery organization.

Powerball is played in 43 states, Washington, D.C., and the U.S. Virgin Islands.

Each state that participates in the game decides how to use the money. Some states earmark the money for a specific purpose, such as education, while others use it in their general funds.

___

Online:

www.powerball.com

Associated Press

Source: http://hosted2.ap.org/APDEFAULT/386c25518f464186bf7a2ac026580ce7/Article_2013-08-04-Powerball%20Jackpot/id-4c8e5f0f41724e5793b536db93e38442

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BUSINESS: Shell takes damaging hit in North American shale patch as Big Oil profits tumble

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Source: http://www.eenews.net/energywire/stories/1059985537/feed

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PraiseWorks Health and Wellness - Total Wellness Mind,Body and ...

DAY TWO ...
Well I have just finished my workout for today!? I was hit with that saying "no pain, no gain".? I guess that is true but for me it just causes me to focus on the "pain"? only. So I have changed my way of thinking when it comes to getting back into shape and meeting my fitness goals.?

"SMILE THROUGH THE TRAIL, PUSH TO SUCCESS and STOP BEIN' A MESS"

That's right.? I am talking to all of us who have made some kind of fitness goal and as soon as it gets a bit tough we want to quit!? Quitting is always an option but it is an option that will NOT help us meet our fitness goals. Let's choose to look at our option and decision to get in shape as:

• positive
• worth doing?
• improving the overall quality of our life
• life affirming
• wellness for our mind, body and spirit.?

After my workout today, I have to tell you I felt such a since of accomplishment and well being. Those endorphins started going and all of a sudden this smile came to my spirit. That is when I decided to "smile through the trail, push to success and stop bein' a mess".? Yup the workout is tough, but the benefits are worth it!?

Here is the work out in case you missed it!?

Source: http://praiseworkshealthandwellness.blogspot.com/2013/08/SmileThroughTheTrail.html

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Stocks end slightly higher after tepid jobs report

markets

Justin Menza CNBC.com

5 hours ago

Spencer Platt / Getty Images

Traders work on the floor of the New York Stock Exchange at the end of the trading day on August 1, 2013 in New York City.

Stocks closed modestly higher in thin volume on Friday despite a tepid jobs report. While the data was disappointing, it still showed job growth and may also make the Federal Reserve a bit more hesitant about curtailing its stimulus policies in September.

The U.S. economy created just 162,000 nonfarm payroll jobs in July after a downwardly revised 188,000 in June. The unemployment rate fell to 7.4 percent.

The quality of the jobs being created is also an issue. Burt White of LPL Financial pointed out, "Over the last four months we've created 4.2 part-time jobs for every one full-time job. That trend is not going in a good direction."

After spending the session clawing back morning losses, the Dow Jones Industrial Average?finished 30 points higher at 15,658.36. The?S&P 500 and Nasdaq ended with slight gains, while both the S&P and Dow set new closing highs.

The CBOE Volatility Index (VIX), widely considered the best gauge of fear in the market, fell to 12.1.

Among S&P sectors, consumer discretionary and materials stocks led the gainers. Energy fell after disappointing earnings from oil giant Chevron.

"I think the market grinds higher," Bob Doll, chief equity strategist at Nuveen Asset Management, said. "We're not going to go up another 18 percent as we have since the first of the year in my opinion. But I think the market ends higher than where it is today."

The jobs data may push back the timing, or at least scale, of a potential Fed tapering of its bond-buying program.

St. Louis Fed president James Bullard said in a speech Friday that the central bank "needs to see more data" before it makes a decision about slowing the pace of its $85 billion-a-month bond-buying program.

(Read more: So-so summer: Job growth disappoints; rate drops)

Some economists, meanwhile, see just a small reduction in bond purchases next month.

"I think they'll only do $15 billion because the evidence will be still somewhat ambiguous," BNY Mellon economist Richard Hoey told CNBC of the potential cutback in bond purchases. "I don't think they'll do $25 billion. That's too strong a measure."

In other data, U.S. consumer spending increased 0.5 percent in June, lifted by automobile purchases and higher gasoline prices. Personal incomes rose 0.3 percent. June factory orders, meanwhile, rose 1.5 percent after an upwardly revised 3 percent in May.

(Read more: Escape velocity hopes give way to law of gravity)

Cable stocks rose on reports that Cox Communications and Charter Communications held merger talks. Cablevision was up sharply as well.

Viacom, meanwhile, reported a 14 percent rise in revenue helped by strong advertising and CBS affiliate fees at its cable networks. The media giant also doubled its stock buyback program to $20 billion.

LinkedIn shares surged following better-than-expected earnings and after a number of brokers hiked their price targets on the social networking firm.

AIG stock rose after the company posted strong earnings and said it would return capital to shareholders.

But oil giant?Chevron posted a 26 percent decline in net income?due to lower oil prices and maintenance work at its U.S. refineries.

Source: http://feeds.nbcnews.com/c/35002/f/663286/s/2f7e7015/sc/2/l/0L0Snbcnews0N0Cbusiness0Cstocks0Eend0Eslightly0Ehigher0Eafter0Etepid0Ejobs0Ereport0E6C10A824614/story01.htm

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Aaron Sinift's ?Five-Year Plan? | BU Today | Boston University

In the slideshow above, view pages from the Five-Year Plan book, a project organized by Aaron Sinift (CFA?02) to help support artists as well as artisans in India.

At seven, Aaron Sinift (CFA?02) told his mother, ?Someday, I?m going to change my name to Harry Whitecloud and travel to India.? When he finally made the trip at the age of 24, he felt as though ?I was returning to an essential facet of my heart.? He loved India?s color, vibrancy, and culture, so different from his native Iowa. He was distressed by the country?s extreme poverty and drawn to the work of the ashrams, service institutions promoted by Mahatma Gandhi to help India?s rural poor maintain self-sufficiency by spinning and weaving khadi cloth. ?The khadi is so beautiful and so fragrant, and rough in certain ways,? Sinift says. ?Gandhi wore it, and it has a lot of soul.?

Sinift bought a traditional jhola [jho-la] shoulder bag made from khadi cloth and printed with an image of Gandhi. ?I was attracted by the tender awkwardness of the artworks created by anonymous ashram artists for common people. These are authentic Pop Art creations from the very roots of the land.? As a CFA graduate student, he hung the jhola on the wall of his studio and found that his bold, colorful paintings began to take on some of the jhola?s themes. His advisor, John Walker, a CFA professor of art, noticed the change. ?That bag is not an artifact,? Walker said. ?It?s a living work of art.? This casual line stuck with Sinift, and it would direct the course of his career.

After graduating from CFA, Sinift took a job as the preparator at a New York gallery, Feature Inc., and painted in his Brooklyn studio with the hope of being discovered. ?I was seeking the approval of people who didn?t know I existed, and I decided to reinvent myself into the person I wanted to become. I wanted to be an artist who serves those in need and to create a community in which people feel connected to one another.?

Sinift invited the ashrams to create a book made entirely from khadi cloth featuring screen- and block-printed artworks by 24 artists from 8 countries. He commissioned well-known artists like Francesco Clemente, Yoko Ono, and Chris Martin, as well as emerging artists such as Tamara Gonzales, Tim Wehrle, and Pushpa Kumari to contribute one page each. He called this project the ?Five-Year Plan? and aimed to print 180 copies, which would be packaged in handmade jhola bags.

Sinift (third from left) with children from the Gandhi Hindustani Sahitya Sabha, one of the ashrams collaborating with him on his "Five-Year Plan" project. Flanking Sinift are Jainendra Jigyasu (far left) and Sushila, both teachers at the ashram. Photo by Jatin

In accordance with Gandhi?s philosophy, the Five-Year Plan would need to be entirely nonprofit and autonomous, so instead of seeking institutional backing to assist with the printing cost, Sinift raised more than half of the funds by preselling the book online. ?Citizen artists need to find ways to fund their work with modest means,? he says. ?When we do so, we realize that we?re not helpless. We realize how much power we have.? Sinift pledged the first $25,000 revenue to Doctors Without Borders and the remaining proceeds to the next Five-Year Plan project. But first, he needed the cloth.

Sinift traveled to the outskirts of New Delhi to find an ashram that would collaborate on the Five-Year Plan. During a visit to an ashram in Meerut, Sinift met with the director, ?a stony guy who was used to people coming to buy their cloth because it?s cheap. When I showed him the drawing that I made for the cover of the book, his eyes began to water. He saw that I respected his labor and was not there to take advantage of it. That was the moment I knew I was on the right track.?

Sinift commissioned 1.4 kilometers, almost a mile, of khadi from the Manav Seva Sannidhi Ashram in Modinagar, which employs 700 spinners, the majority of whom are women over the age of 55. The ashram also employs 45 weavers (mostly men over the age of 45), and 35 helpers. Most of these workers are Dalit Muslim or low-caste Hindu, and are the sole providers for their families. Spinning and weaving the khadi for the Five-Year Plan created more than 2,400 days of work for the ashram and kept 100 families employed for a month.

The artisans of the Manav Seva Sannidhi Ashram wove, printed, and embroidered a limited edition of 50 jholas that can be purchased at www.5yearplan.org. All proceeds will help support Sinift?s Five-Year-Plan project, in collaboration with the ashrams. Photo by Vernon Doucette

The artists, too, benefited from the Five-Year Plan. ?Most of the artists are very poor,? Sinift says. Each artist received a copy signed by all of the contributors, and ?they can sell their copies of the book and use the proceeds however they wish.? Indian painter Pushpa Kumari, whose intricate work is inspired by stories from the Hindu epics, is using the proceeds from the sale of her book to help build her house. True to Gandhi?s ideals, Sinift has not profited from the Five-Year Plan; to support his life and his art, he works part time at the Smithsonian?s Hirshhorn Museum and Sculpture Garden in Washington, D.C., and the Katzen Arts Center at American University, which he finds as fulfilling as his work with the ashrams.

And Sinift is just getting started. He plans eventually to take the project a step further by beginning a book from seeds, commissioning organic farmers in India to grow one ton of cotton that will be spun into the thread used to weave the khadi. He will invite the farmers, spinners, and weavers to contribute original artworks, completing a ?sustainable cycle of collaboration.?

?The ashram workers provide incredible value to the world by supporting Gandhian ethics and helping people to maintain self-sufficiency,? Sinift says. ?The people in Doctors Without Borders dedicate their lives to saving people in crisis. The Five-Year Plan gives artists a chance to make a tangible contribution to the common good, simply by doing what they already do naturally. If people just give what they do naturally, everyone can live together with dignity.?

Lara Ehrlich can be reached at lehrlich@bu.edu.

A version of this article was originally published in the spring 2013 edition of Esprit.

Source: http://www.bu.edu/today/2013/aaron-sinift-five-year-plan/

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Bangladesh court rules top Islamic party illegal

DHAKA (Reuters) - A Bangladesh court on Thursday declared as illegal the country's main Islamic party, Jamaat-e-Islami, effectively banning it from national elections due to be held early next year.

The ruling that the registration of Jamaat as a political party conflicted with the country's secular constitution immediately triggered violent protests by party supporters.

Hundreds of activists blocked a major road and smashed vehicles in Pabna district, northwest of the capital, police said. Further protests were anticipated throughout the afternoon and evening.

Jamaat immediately appealed to the Supreme Court against the High Court verdict, senior defense lawyer Abdur Razzak told reporters. The party would be barred from contesting elections if the Supreme Court upholds the verdict.

More than 100 people have been killed in protests and counter-protests since January, when a tribunal set up by the government to investigate alleged abuses in the country's 1971 war of independence sentenced to death in absentia a former senior Jamaat figure.

Jamaat opposed Bangladeshi independence from Pakistan in the war but denies accusations that some of its leaders committed murder, rape and torture during the conflict.

(Reporting by Ruma Paul; Editing by John Chalmers and Ron Popeski)

Source: http://news.yahoo.com/bangladesh-court-rules-top-islamic-party-illegal-110904670.html

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